Megamind (2010)

Supervillain Megamind and his arch-nemesis, the superhero Metro Man, were both infants that were sent to Earth by their dying planets. Though both arrived in Metro City at the same time, Metro Man was raised in a mansion, while Megamind was raised by prisoners. In the present, Megamind, aided by his fish-like companion Minion, frequently and unsuccessfully battles Metro Man for control of the city. At the grand opening of the new Metro Man Museum, Megamind escapes his prison, kidnaps reporter Roxanne Ritchi, and lures Metro Man to an abandoned observatory to rescue her. Once there, Metro Man collapses, claiming the copper-lined observatory roof weakens his powers; Megamind then shoots (and apparently kills) Metro Man with a sun-powered weapon. With no one around to stop him, Megamind goes on a crime spree, taking over the city; however, he feels increasingly depressed and purposeless with no hero to fight.

Megamind decides to blow up the Metro Man museum to forget the hero, but sees Roxanne there and dehydrates the museum’s curator, Bernard, into a small cube instead. Disguised as Bernard using hologram technology, Megamind talks to Roxanne, whose remarks inspire him to use Metro Man’s DNA to create a new superhero to fight. Megamind perfects the formula, but accidentally injects it into Hal Stewart, Roxanne’s dimwitted cameraman who has a crush on her.