Spider-Man 2 (2004)

Peter Parker is estranged from both his love interest Mary Jane Watson and his best friend Harry Osborn and discovers that his aunt May is facing eviction. He finds himself suffering temporary but recurring losses of his powers, often in life-threatening situations. Harry, who is now head of Oscorp’s genetic and scientific research division, is sponsoring a fusion power project by nuclear scientist Otto Octavius, who befriends and mentors Peter. While handling hazardous materials, Octavius wears a harness of powerful robotic tentacle arms with artificial intelligence.

During a public demonstration that Peter and Harry attend, a power spike causes the fusion reactor to destabilize. Octavius refuses to shut down the reactor, which goes critical, killing his wife and burning the inhibitor chip blocking the arms from his nervous system. Spider-Man shuts the experiment down. At a hospital, doctors prepare to surgically remove Octavius’ harness. Without the inhibitor chip, the now sentient arms defend themselves by killing the doctors. Octavius takes refuge at a harbor. Now corrupted by the arms’ AI, he decides to re-try his experiment and robs a bank to fund it. The Daily Bugle dubs the scientist “Doctor Octopus”.